1589Incidence and Risk factors of Hepatitis C Virus Infection among HIV Patients in a large HIV Clinic in South Korea

Background. Increasing incidences of HCV infection in MSM with HIV infections were reported in the United States and Europe. However, there are few studies regarding the epidemiology of HCV in HIV infected patients in Asian countries. Methods. To determine the risk factors of HCV infection, and the incidence of HCV in in HIV infected patients, a retrospective cohort study was performed. All HIV infected patients who visited Pusan National University hospital from January 2000 to October 2013 were identified from the computerized records. The patients with a negative baseline anti-HCV antibody who had subsequent anti-HCV antibody tests more than 6 months apart were included. Demographic and clinical data were reviewed, retrospectively. For analysis of risk factors, a multivariable logistic regression model was used. Results. Among 996 HIV patients, 790 (79%) had baseline anti-HCVAntibody tests and 41 (5.2%) were positive for anti-HCVAb. In a multivariable analysis, widowed or divorced marital status (adjusted odds ratio 2.67; 95% confidence interval 1.17-6.08, P = 0.02), HIV transmission by intravenous drug use (IDU) (aOR 66.08; 95% CI 16.31-267.69, P < 0.01) and blood exposure other than IDU (aOR 42.34; 95% CI 4.13433.74, P < 0.01) were significantly associated with HCV infection in HIV patients. Of 330 patients with subsequent anti HCVAb tests, were observed for 1527.94 person years and 4 patients (1MSM and 3 IDU) had HCV seroconversion with incidence rate of 2.64/ 1,000 person years (PYs); 130.89/1,000 PYs in IV Drug user, 1.65/1,000 PYs in MSM, and 0/1,000 PYs in the heterosexual. Incidence rate of HCV was increased in recent 5 years [0 (2000∼ 2,009) vs 4.58 (2010∼ 2014)/1,000 PYs] although incidence of syphilis was constant [53.81 (2000∼ 2009) vs 48.85 (2010∼ 2014)/1,000 PYs]. All of the incident HCV infections were developed within recent 5 years. Among 34 patients with available HCV RNA results, 19 patients were positive for HCV RNA and genotype 1b (73%) was most common following 2a/2c (20%). Conclusion. Incidence rate of HIV infected patients was 2.64/1,000 PYs. Widowed/divorced marital status, HIV transmission by intravenous drug use were independent risk factors for HCV infection in HIV patients. Although the seroconversion of anti-HCV was not frequent yet, the incidence of HCV infection is increasing in HIV infection in South Korea. Disclosures. All authors: No reported disclosures.